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PHF20 Methyllysine-binding protein, component of the MOF histone acetyltransferase protein complex. Not required for maintaining the global histone H4 'Lys-16' acetylation (H4K16ac) levels or locus specific histone acetylation, but instead works downstream in transcriptional regulation of MOF target genes. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. Component of some MLL1/MLL complex, at least composed of the core components MLL, ASH2L, HCFC1, WDR5 and RBBP5, as well as the facultative components C17orf49, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, KAT8/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Component of the NSL complex at least composed of MOF/KAT8, KANSL1, KANSL2, KANSL3, MCRS1, PHF20, OGT1/OGT, WDR5 and HCFC1. Expressed in heart, kidney, liver, lung, pancreas, placenta, spleen and testis. Not expressed in brain, skeletal muscle, colon, ovary, prostate, small intestine and thymus. Expressed in colon and ovary cancer cell lines while it is not expressed in the respective normal tissues. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Acetyltransferase; C2H2-type zinc finger protein; DNA-binding; Nuclear envelope
Chromosomal Location of Human Ortholog: 20q11.22-q11.23
Cellular Component: cytosol; histone acetyltransferase complex; nuclear membrane; nucleoplasm
Molecular Function: histone acetyltransferase activity (H4-K16 specific); protein binding
Biological Process: positive regulation of transcription from RNA polymerase II promoter
Reference #:  Q9BVI0 (UniProtKB)
Alt. Names/Synonyms: C20orf104; FLJ33479; GLEA2; Glioma-expressed antigen 2; HCA58; Hepatocellular carcinoma-associated antigen 58; NZF; PHD finger protein 20; PHF20; Transcription factor TZP; TZP
Gene Symbols: PHF20
Molecular weight: 115,386 Da
Basal Isoelectric point: 6.55  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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