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ARIH2 E3 ubiquitin-protein ligase mediating 'Lys-48'-and 'Lys- 63'-linked polyubiquitination and subsequent proteasomal degradation of modified proteins. May play a role in myelopoiesis. Belongs to the RBR family. Ariadne subfamily. Note: This description may include information from UniProtKB.
Protein type: EC 6.3.2.-; Ligase; Ubiquitin conjugating system; Ubiquitin ligase
Chromosomal Location of Human Ortholog: 3p21.31
Cellular Component: Cul5-RING ubiquitin ligase complex; cytoplasm; nucleoplasm; nucleus
Molecular Function: protein binding; ubiquitin conjugating enzyme binding; ubiquitin-protein ligase activity; zinc ion binding
Biological Process: developmental cell growth; multicellular organismal development; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; protein polyubiquitination; protein ubiquitination; protein ubiquitination during ubiquitin-dependent protein catabolic process
Reference #:  O95376 (UniProtKB)
Alt. Names/Synonyms: all-trans retinoic acid inducible RING finger; ARI-2; ARI2; ariadne homolog 2 (Drosophila); ARIH2; FLJ10938; FLJ33921; Protein ariadne-2 homolog; TRIAD1; Triad1 protein
Gene Symbols: ARIH2
Molecular weight: 57,819 Da
Basal Isoelectric point: 5.4  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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