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rubicon Negatively regulates endocytic trafficking. Impairs the autophagosome maturation process. May inhibit PIK3C3 activity. Forms a complex with BECN1, PIK3C3, PIK3R4 and UVRAG, but not with ATG14. The complex containing ATG14 up-regulates autophagy, while the one containing Rubicon down-regulates autophagy. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Unknown function
Chromosomal Location of Human Ortholog: 3q29
Cellular Component: cytosol; early endosome; Golgi apparatus; intracellular membrane-bound organelle; late endosome; nucleoplasm
Molecular Function: protein binding
Biological Process: negative regulation of autophagy; negative regulation of endocytosis; negative regulation of phosphoinositide 3-kinase activity
Disease: Spinocerebellar Ataxia, Autosomal Recessive 15
Reference #:  Q92622 (UniProtKB)
Alt. Names/Synonyms: hypothetical protein LOC9711; K0226; KIAA0226; Uncharacterized protein KIAA0226
Gene Symbols: RUBCN
Molecular weight: 108,622 Da
Basal Isoelectric point: 5.86  Predict pI for various phosphorylation states
CST Pathways:  Autophagy Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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