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TweakR Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins. Associates with TRAF1 and TRAF2, and probably also with TRAF3. By FGF1 and phorbol ester. Highly expressed in heart, placenta and kidney. Intermediate expression in lung, skeletal muscle and pancreas. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cell development/differentiation; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.
Chromosomal Location of Human Ortholog: 16p13.3
Cellular Component: plasma membrane
Molecular Function: protein binding
Biological Process: positive regulation of apoptosis; tumor necrosis factor-mediated signaling pathway
Reference #:  Q9NP84 (UniProtKB)
Alt. Names/Synonyms: FGF-inducible 14; fibroblast growth factor-inducible immediate-early response protein 14; FN14; TNFRSF12A; tumor necrosis factor receptor superfamily member 12A; tweak-receptor; type I transmembrane protein Fn14; TweakR
Gene Symbols: TNFRSF12A
Molecular weight: 13,911 Da
Basal Isoelectric point: 9.37  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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