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LAMTOR2 Adapter protein that enhances the efficiency of the MAP kinase cascade. Facilitates the activation of MAPKAPK2 . Heterodimer with MAP2K1IP1. Interacts with ERK and MEK1. Defects in ROBLD3 are the cause of immunodeficiency due to defect in MAPBP-interacting protein. This form of primary immunodeficiency syndrome includes congenital neutropenia, partial albinism, short stature and B-cell and cytotoxic T-cell deficiency. Two alternatively spliced isoforms of the human protein have been described. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 1q22
Cellular Component: endosome membrane; late endosome; lysosomal membrane; plasma membrane
Molecular Function: guanyl-nucleotide exchange factor activity; protein binding; protein complex scaffold activity
Biological Process: activation of MAPKK activity; cell cycle arrest; cell growth; MAPK cascade; neutrophil degranulation; positive regulation of GTPase activity; positive regulation of TOR signaling pathway; regulation of macroautophagy
Disease: Immunodeficiency Due To Defect In Mapbp-interacting Protein
Reference #:  Q9Y2Q5 (UniProtKB)
Alt. Names/Synonyms: ENDAP; endosomal adaptor protein p14; HSPC003; late endosomal/lysosomal adaptor, MAPK and MTOR activator 2; late endosomal/lysosomal Mp1-interacting protein; MAPBPIP; MAPKSP1 adaptor protein; MAPKSP1AP; mitogen-activated protein-binding protein-interacting protein; P14; Ragulator2; roadblock domain containing 3; roadblock domain-containing protein 3; ROBLD3
Gene Symbols: LAMTOR2
Molecular weight: 13,508 Da
Basal Isoelectric point: 5.3  Predict pI for various phosphorylation states
CST Pathways:  Growth And Differentiation Control by MAPKs
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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