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RRAGA Has guanine nucleotide-binding activity but undetectable intrinsic GTPase activity. Required for the amino acid-induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids. Involved in the RCC1/Ran-GTPase pathway. May play a direct role in a TNF- alpha signaling pathway leading to induction of cell death. May alternatively act as a cellular target for adenovirus E3-14.7K, an inhibitor of TNF-alpha functions, thereby affecting cell death. Can occur as a homodimer, or form a heterodimer with RRAGC or RRAGD in a sequence-independent manner. Binds GTP. The GTP-bound form of RRAGA interacts with NOL8. Interacts with adenovirus E3 14.7 kDa protein. Ubiquitously expressed with highest levels of expression in skeletal muscle, heart, and brain. Belongs to the GTR/RAG GTP-binding protein family. Note: This description may include information from UniProtKB.
Protein type: G protein regulator, misc.
Chromosomal Location of Human Ortholog: 9p22.1
Cellular Component: cytoplasm; cytosol; lysosomal membrane; lysosome; nucleus
Molecular Function: GTP binding; GTPase activity; phosphoprotein binding; protein binding; protein heterodimerization activity; protein homodimerization activity; ubiquitin protein ligase binding
Biological Process: cell cycle arrest; cell death; cellular response to amino acid starvation; negative regulation of autophagy; positive regulation of cytolysis; protein ubiquitination; regulation of macroautophagy; virus-host interaction
Reference #:  Q7L523 (UniProtKB)
Alt. Names/Synonyms: Adenovirus E3 14.7 kDa-interacting protein 1; FIP-1; FIP1; Rag A; RagA; Ras-related GTP binding A; RRAGA
Gene Symbols: RRAGA
Molecular weight: 36,566 Da
Basal Isoelectric point: 7.62  Predict pI for various phosphorylation states
CST Pathways:  mTOR Signaling  |  Translation: eIF4E and p70S6K
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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