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TRAIL-R2 Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF- kappa-B. Homotrimer. Can interact with TRADD and RIPK1. Regulated by p53/TP53. Widely expressed in adult and fetal tissues; very highly expressed in tumor cell lines such as HeLaS3, K-562, HL-60, SW480, A-549 and G-361; highly expressed in heart, peripheral blood lymphocytes, liver, pancreas, spleen, thymus, prostate, ovary, uterus, placenta, testis, esophagus, stomach and throughout the intestinal tract; not detectable in brain. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 8p21.3
Cellular Component: cell surface; integral to membrane; integral to plasma membrane; plasma membrane
Molecular Function: protein binding; tumor necrosis factor receptor activity
Biological Process: caspase activation; cell surface receptor linked signal transduction; immune response; inflammatory response; leukocyte migration; multicellular organismal development; negative regulation of caspase activity; positive regulation of I-kappaB kinase/NF-kappaB cascade; regulation of apoptosis; regulation of cell proliferation; response to lipopolysaccharide
Disease: Squamous Cell Carcinoma, Head And Neck
Reference #:  O14763 (UniProtKB)
Alt. Names/Synonyms: CD262; death receptor 5; DR5; KILLER; TNFRSF10B; TRAILR2; TRICK2; tumor necrosis factor receptor superfamily, member 10b; ZTNFR9
Gene Symbols: TNFRSF10B
Molecular weight: 47,878 Da
Basal Isoelectric point: 5.39  Predict pI for various phosphorylation states
CST Pathways:  Death Receptor Signaling
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