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TDGF1 Could play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm. Interacts with the activin type-1 receptor ACVR1B. Preferentially expressed in gastric and colorectal carcinomas than in their normal counterparts. Expressed in breast and lung. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Cell cycle regulation; Membrane protein, GPI anchor; Membrane protein, peripheral; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 9 F2|9 60.79 cM
Cellular Component: apical plasma membrane; cell surface; cytoplasm; extracellular region; extracellular space; extrinsic to plasma membrane; Golgi apparatus; lipid raft; nucleus; perinuclear region of cytoplasm
Molecular Function: coreceptor activity; growth factor activity; protein binding; receptor binding; Wnt-protein binding
Biological Process: activation of MAPK activity; anterior/posterior axis specification; BMP signaling pathway; cardiac muscle cell differentiation; cell differentiation; cell migration during sprouting angiogenesis; determination of anterior/posterior axis, embryo; epidermal growth factor receptor signaling pathway; gastrulation; heart development; in utero embryonic development; morphogenesis of a branching structure; negative regulation of apoptosis; negative regulation of transforming growth factor beta receptor signaling pathway; peptidyl-serine phosphorylation; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of cell-matrix adhesion; positive regulation of fibroblast proliferation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of transcription from RNA polymerase II promoter; regulation of cell migration; regulation of signal transduction; vasculogenesis; Wnt receptor signaling pathway through beta-catenin
Reference #:  P51865 (UniProtKB)
Alt. Names/Synonyms: CR1; Cripto; Cripto growth factor; Epidermal growth factor-like Cripto protein; Tdgf1; teratocarcinoma-derived growth factor 1
Gene Symbols: Tdgf1
Molecular weight: 18,754 Da
Basal Isoelectric point: 8.21  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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