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TDGF1 Could play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm. Interacts with the activin type-1 receptor ACVR1B. Preferentially expressed in gastric and colorectal carcinomas than in their normal counterparts. Expressed in breast and lung. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Cell cycle regulation; Membrane protein, GPI anchor; Membrane protein, peripheral; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 3p21.31
Cellular Component: apical plasma membrane; cell surface; extracellular space; extrinsic to plasma membrane; lipid raft; plasma membrane
Molecular Function: growth factor activity; protein binding; receptor binding
Biological Process: activation of MAPK activity; cell differentiation; cell migration during sprouting angiogenesis; determination of anterior/posterior axis, embryo; embryonic development; epidermal growth factor receptor signaling pathway; heart development; mammary gland development; morphogenesis of a branching structure; negative regulation of apoptosis; peptidyl-serine phosphorylation; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of peptidyl-tyrosine phosphorylation; regulation of signal transduction; somatic stem cell maintenance
Reference #:  P13385 (UniProtKB)
Alt. Names/Synonyms: CR; CRGF; CRIPTO; Epidermal growth factor-like cripto protein CR1; TDGF1; teratocarcinoma-derived growth factor 1
Gene Symbols: TDGF1
Molecular weight: 21,169 Da
Basal Isoelectric point: 8.54  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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