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IL13 Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. Defects in IL13 may be a cause of susceptibility to allergic rhinitis (ALRH). Allergic rhinitis is a common disease of complex inheritance and is characterized by mucosal inflammation caused by allergen exposure. Belongs to the IL-4/IL-13 family. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 11 B1.3|11 31.98 cM
Cellular Component: cytoplasm; external side of plasma membrane; extracellular region; extracellular space
Molecular Function: interleukin-13 receptor binding
Biological Process: inflammatory response; microglial cell activation; negative regulation of NAD(P)H oxidase activity; positive regulation of B cell proliferation; positive regulation of connective tissue growth factor production; positive regulation of immunoglobulin production; positive regulation of ion transport; positive regulation of macrophage activation; positive regulation of mast cell degranulation; positive regulation of protein secretion; positive regulation of release of sequestered calcium ion into cytosol; positive regulation of smooth muscle cell proliferation; positive regulation of tyrosine phosphorylation of STAT protein; regulation of proton transport; response to nicotine
Reference #:  P20109 (UniProtKB)
Alt. Names/Synonyms: Il-13; Il13; interleukin 13; interleukin-13; T-cell activation protein P600
Gene Symbols: Il13
Molecular weight: 14,108 Da
Basal Isoelectric point: 8.34  Predict pI for various phosphorylation states
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Protein Structure Not Found.
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