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IL8 IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus. IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity on neutrophil activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively. Belongs to the intercrine alpha (chemokine CxC) family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cytokine; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 4q13.3
Cellular Component: extracellular region; extracellular space
Molecular Function: chemokine activity; interleukin-8 receptor binding; protein binding
Biological Process: angiogenesis; calcium-mediated signaling; cell cycle arrest; cell motility; chemotaxis; embryonic gut development; G-protein coupled receptor protein signaling pathway; immune response; induction of positive chemotaxis; inflammatory response; negative regulation of cell proliferation; negative regulation of G-protein coupled receptor protein signaling pathway; neutrophil activation; neutrophil chemotaxis; positive regulation of angiogenesis; receptor internalization; regulation of cell adhesion; regulation of retroviral genome replication; response to molecule of bacterial origin; signal transduction
Reference #:  P10145 (UniProtKB)
Alt. Names/Synonyms: C-X-C motif chemokine 8; CXCL8; emoctakin; GCP-1; granulocyte chemotactic protein 1; IL-8; IL8; Interleukin-8; lymphocyte-derived neutrophil-activating factor; LYNAP; MDNCF; MONAP; monocyte-derived neutrophil chemotactic factor; monocyte-derived neutrophil-activating peptide; NAP-1; Neutrophil-activating protein 1; Protein 3-10C; small inducible cytokine subfamily B, member 8; T cell chemotactic factor; T-cell chemotactic factor
Gene Symbols: CXCL8
Molecular weight: 11,098 Da
Basal Isoelectric point: 9.1  Predict pI for various phosphorylation states
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