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NT-4/5 Target-derived survival factor for peripheral sensory sympathetic neurons. Defects in NTF4 may be associated with susceptibility to primary open angle glaucoma type 1O (GLC1O). A form of primary open angle glaucoma (POAG). POAG is characterized by a specific pattern of optic nerve and visual field defects. The angle of the anterior chamber of the eye is open, and usually the intraocular pressure is increased. The disease is asymptomatic until the late stages, by which time significant and irreversible optic nerve damage has already taken place. Belongs to the NGF-beta family. Note: This description may include information from UniProtKB.
Protein type: Cell development/differentiation; Cytokine; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 19q13.33
Cellular Component: cytoplasmic vesicle; endoplasmic reticulum lumen; extracellular region
Molecular Function: growth factor activity; neurotrophin p75 receptor binding; protein binding
Biological Process: adult locomotory behavior; cell-cell signaling; epidermis development; ganglion mother cell fate determination; long-term memory; negative regulation of neuron apoptosis; neurite morphogenesis; regulation of neuron differentiation; sensory organ boundary specification; transmembrane receptor protein tyrosine kinase signaling pathway
Disease: Glaucoma 1, Open Angle, O
Reference #:  P34130 (UniProtKB)
Alt. Names/Synonyms: GLC10; GLC1O; neurotrophin 4; NT4; NTF4; NTF5
Gene Symbols: NTF4
Molecular weight: 22,427 Da
Basal Isoelectric point: 9.01  Predict pI for various phosphorylation states
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Protein Structure Not Found.
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