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LAMTOR3 Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. As part of the Ragulator complex, recruits the Rag GTPases and the mTORC1 complex to lysosomes, a key step in activation of the TOR signaling cascade by amino acids. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2. Interacts with MAP2K1/MEK1 and MAPK2. Interacts with MORG1. Part of the Ragulator complex composed of LAMTOR1, LAMTOR2 and LAMTOR3. Interacts with LAMTOR1; the interaction is direct. Belongs to the LAMTOR3 family. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 4q23
Cellular Component: endosome membrane; focal adhesion; lysosomal membrane; plasma membrane
Molecular Function: guanyl-nucleotide exchange factor activity; protein binding; protein complex scaffold
Biological Process: cell cycle arrest; MAPKKK cascade; neutrophil degranulation; positive regulation of TOR signaling pathway; regulation of macroautophagy
Reference #:  Q9UHA4 (UniProtKB)
Alt. Names/Synonyms: MAP2K1IP1; MAPK scaffold protein 1; MAPKSP1; MEK-binding partner 1; Mitogen-activated protein kinase kinase 1-interacting protein 1; Mitogen-activated protein kinase scaffold protein 1; MPKS1; PRO2783
Gene Symbols: LAMTOR3
Molecular weight: 13,623 Da
Basal Isoelectric point: 6.72  Predict pI for various phosphorylation states
CST Pathways:  Growth And Differentiation Control by MAPKs
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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