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TPT1 a novel heat shock protein with antiapoptotic and chaperone-like activity. Its levels are highly regulated in response to various cellular stimuli and stresses. Downregulated in response to proapoptotic treatments that induce Ca(++) stress, in a PKR-dependent manner. Colocalizes with CHFR to the mitotic spindle. Appears to be involved in calcium binding and microtubule stabilization. Its exosomal secretion is induced following DNA damage. Interacts with MCL1 and STEAP3, a p53-inducible transmembrane protein that facilitates the exosomal secretion of TPT1. Secreted TPT1 acts as a histamine-releasing factor, participates in inflammatory responses by inducing the release of histamine, and may play a role in tumor reversion. May play a direct role in placental calcium transport. Phosphorylation by Plk may decrease its microtubule-stabilizing activity and promote microtubule dynamics following metaphase. Critical for peripheral T cell maintenance and TCR-mediated cell proliferation. Note: This description may include information from UniProtKB.
Protein type: Calcium-binding; Microtubule-binding
Chromosomal Location of Human Ortholog: 13q14.13
Cellular Component: cytoplasm; cytosol; extracellular space; multivesicular body; nucleus; tubulin complex
Molecular Function: calcium ion binding; microtubule binding; protein binding; RNA binding
Biological Process: calcium ion transport; cell differentiation; cellular calcium ion homeostasis; negative regulation of apoptosis; response to virus
Reference #:  P13693 (UniProtKB)
Alt. Names/Synonyms: FLJ27337; Fortilin; Histamine-releasing factor; HRF; p02; p23; TCTP; TPT1; Translationally-controlled tumor protein; tumor protein, translationally-controlled 1
Gene Symbols: TPT1
Molecular weight: 19,595 Da
Basal Isoelectric point: 4.84  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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