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DNMT3L Catalytically inactive regulatory factor of DNA methyltransferases. It is essential for the function of DNMT3A and DNMT3B. Activates DNMT3A and DNMT3B by binding to their catalytic domain. Accelerates the binding of DNA and AdoMet to the methyltransferases and dissociates from the complex after DNA binding to the methyltransferases. Recognizes unmethylated histone H3 lysine 4 (H3K4) and induces de novo DNA methylation by recruitment or activation of DNMT3. Belongs to the C5-methyltransferase family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - cysteine and methionine; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 21q22.3
Cellular Component: cytosol; ESC/E(Z) complex; nucleus
Molecular Function: enzyme activator activity; enzyme binding; protein binding
Biological Process: DNA methylation during gametogenesis; DNA methylation on cytosine; male meiosis I; negative regulation of transcription, DNA-dependent; spermatogenesis; stem cell differentiation
Reference #:  Q9UJW3 (UniProtKB)
Alt. Names/Synonyms: cytosine-5-methyltransferase 3-like protein; DNA (cytosine-5)-methyltransferase 3-like; DNA (cytosine-5-)-methyltransferase 3-like; DNM3L; DNMT3L; human cytosine-5-methyltransferase 3-like protein; MGC1090
Gene Symbols: DNMT3L
Molecular weight: 43,583 Da
Basal Isoelectric point: 5.59  Predict pI for various phosphorylation states
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Protein Structure Not Found.
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