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ATG4B Cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes. Mainly expressed in the skeletal muscle, followed by brain, heart, liver and pancreas. Inhibited by N-ethylmaleimide. Belongs to the peptidase C54 family. 5 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Autophagy; EC 3.4.22.-; Protease; Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 2q37.3
Cellular Component: cytoplasm; cytosol
Molecular Function: cysteine-type endopeptidase activity; cysteine-type peptidase activity; endopeptidase activity; protein binding
Biological Process: autophagic vacuole formation; autophagy; C-terminal protein lipidation; macroautophagy; mitochondrion degradation; protein delipidation; protein targeting to membrane; proteolysis
Reference #:  Q9Y4P1 (UniProtKB)
Alt. Names/Synonyms: APG4 autophagy 4 homolog B; APG4B; ATG4 autophagy related 4 homolog B (S. cerevisiae); ATG4B; AUT-like 1 cysteine endopeptidase; AUTL1; Autophagin-1; Autophagy-related cysteine endopeptidase 1; Autophagy-related protein 4 homolog B; Cysteine protease ATG4B; hAPG4B; KIAA0943; MGC1353
Gene Symbols: ATG4B
Molecular weight: 44,294 Da
Basal Isoelectric point: 4.91  Predict pI for various phosphorylation states
CST Pathways:  Autophagy Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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