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ARHGAP3 GTPase-activating protein for p21-rac. Insufficient expression of beta-2 chimaerin is expected to lead to higher Rac activity and could therefore play a role in the progression from low-grade to high-grade tumors. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: GAP; GAP, Rac/Rho
Chromosomal Location of Human Ortholog: 7p14.3
Cellular Component: cytoplasm; cytosol
Molecular Function: GTPase activator activity; protein binding; SH3/SH2 adaptor activity
Biological Process: regulation of GTPase activity; regulation of small GTPase mediated signal transduction
Reference #:  P52757 (UniProtKB)
Alt. Names/Synonyms: ARHGAP3; BCH; beta chimerin; Beta-chimaerin; Beta-chimerin; chimerin (chimaerin) 2; CHIO; CHN2; MGC138360; Rho GTPase-activating protein 3; rho-GTPase-activating protein 3; RHOGAP3
Gene Symbols: CHN2
Molecular weight: 53,924 Da
Basal Isoelectric point: 7.04  Predict pI for various phosphorylation states
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Protein Structure Not Found.
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