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TOLLIP Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Recruits IRAK1 to the IL-1 receptor complex. Inhibits IRAK1 phosphorylation and kinase activity. Oligomerizes. Binds to TLR2 and the TLR4-MD2 complex via its C-terminus. Exists as complex with IRAK1 in unstimulated cells. Upon IL-1 signaling, Tollip binds to the activated IL-1 receptor complex containing IL-1RI, IL-1RacP and the adapter protein MyD88, where it interacts with the TIR domain of IL-1RacP. MyD88 then triggers IRAK1 autophosphorylation, which in turn leads to the dissociation of IRAK1 from Tollip and IL-1RAcP. Interacts with TOM1L2. Belongs to the tollip family. Note: This description may include information from UniProtKB.
Protein type: Inhibitor; Vesicle
Chromosomal Location of Human Ortholog: 11p15.5
Cellular Component: cytoplasm; cytosol; extracellular region
Molecular Function: kinase binding; protein binding; ubiquitin binding; ubiquitin conjugating enzyme binding
Biological Process: cell-cell signaling; epithelial cell differentiation; neutrophil degranulation; phosphorylation; signal transduction; ubiquitin-dependent protein catabolic process
Reference #:  Q9H0E2 (UniProtKB)
Alt. Names/Synonyms: adapter protein; FLJ33531; IL-1RAcPIP; TOLIP; toll interacting protein; Toll-interacting protein; TOLLIP
Gene Symbols: TOLLIP
Molecular weight: 30,282 Da
Basal Isoelectric point: 5.68  Predict pI for various phosphorylation states
CST Pathways:  Toll-Like Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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