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HSP40 a chaperone protein that translocates rapidly from the cytoplasm to the nucleus, and especially to the nucleoli, upon heat shock.Interacts with HSP70 and can stimulate its ATPase activity. Stimulates the association between HSC70 and HIP. Interacts with DNAJC3. Interacts with SRPK1. Note: This description may include information from UniProtKB.
Protein type: Chaperone; Nucleolus
Chromosomal Location of Human Ortholog: 19p13.12
Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus
Molecular Function: ATPase activator activity; ATPase binding; cadherin binding; chaperone binding; Hsp70 protein binding; protein binding; unfolded protein binding
Biological Process: positive regulation of ATPase activity; response to unfolded protein
Reference #:  P25685 (UniProtKB)
Alt. Names/Synonyms: DnaJ (Hsp40) homolog, subfamily B, member 1; DnaJ (Hsp40) homolog, subfmaily B, member 1; DnaJ homolog subfamily B member 1; DnaJ protein homolog 1; DNAJ1; DNAJB1; DNJB1; hDj-1; HDJ1; Heat shock 40 kDa protein 1; heat shock 40kD protein 1; Heat shock protein 40; HSP40; HSPF1; Human DnaJ protein 1; radial spoke 16 homolog B; RSPH16B; Sis1
Gene Symbols: DNAJB1
Molecular weight: 38,044 Da
Basal Isoelectric point: 8.74  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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