a Ser/Thr phosphatase. Plays a role in the survival of cells in a low oxygen stress by suppressing a hypoxia-induced ASK-1/MKK4/JNK signaling cascade that promotes apoptosis. Has been reported to interact with DNA-PK, dephosphorylating it at two functional sites. May play a role in the regulation of RNA biogenesis and/or mitosis. Note: This description may include information from UniProtKB.
Protein type: EC 220.127.116.11; Protein phosphatase, Ser/Thr (non-receptor)
Cellular Component: cytosol; intracellular membrane-bound organelle; nucleoplasm; nucleus; protein complex
Molecular Function: ADP binding; ATP binding; Hsp90 protein binding; identical protein binding; phosphoprotein phosphatase activity; protein binding; protein serine/threonine phosphatase activity; signal transducer activity
Biological Process: MAPKKK cascade; mitotic cell cycle; positive regulation of I-kappaB kinase/NF-kappaB cascade; protein amino acid dephosphorylation; transcription, DNA-dependent