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PPP5C a Ser/Thr phosphatase. Plays a role in the survival of cells in a low oxygen stress by suppressing a hypoxia-induced ASK-1/MKK4/JNK signaling cascade that promotes apoptosis. Has been reported to interact with DNA-PK, dephosphorylating it at two functional sites. May play a role in the regulation of RNA biogenesis and/or mitosis. Note: This description may include information from UniProtKB.
Protein type: EC; Protein phosphatase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 19q13.32
Cellular Component: cytosol; intracellular membrane-bound organelle; nucleoplasm; nucleus; protein complex
Molecular Function: ADP binding; ATP binding; Hsp90 protein binding; identical protein binding; phosphoprotein phosphatase activity; protein binding; protein serine/threonine phosphatase activity; signal transducer activity
Biological Process: MAPKKK cascade; mitotic cell cycle; positive regulation of I-kappaB kinase/NF-kappaB cascade; protein amino acid dephosphorylation; transcription, DNA-dependent
Reference #:  P53041 (UniProtKB)
Alt. Names/Synonyms: FLJ36922; PP-T; PP5; PPP5; PPP5C; PPT; protein phosphatase 5, catalytic subunit; Protein phosphatase T; Serine/Threonine phosphatase; Serine/threonine-protein phosphatase 5
Gene Symbols: PPP5C
Molecular weight: 56,879 Da
Basal Isoelectric point: 5.88  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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