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MOB1B Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38L. Binds STK38L. Interacts with LATS1 and LATS2. Adrenal gland, bone marrow, brain, lung, placenta, prostate, salivary gland, skeletal muscle, testis, thymus, thyroid gland, uterus, colon with mucosa, fetal brain and fetal liver. Belongs to the MOB1/phocein family. Note: This description may include information from UniProtKB.
Protein type: Activator; Protein kinase, regulatory subunit
Chromosomal Location of Human Ortholog: 4q13.3
Cellular Component: cytoplasm; cytosol; nucleolus; nucleus
Molecular Function: kinase activator activity; kinase binding; protein binding
Biological Process: regulation of protein amino acid autophosphorylation
Reference #:  Q7L9L4 (UniProtKB)
Alt. Names/Synonyms: MATS2; MGC33910; Mob1 homolog 1A; MOB1, Mps One Binder kinase activator-like 1A (yeast); Mob1A; Mob1B; MOB4A; MOBKL1A; MOL1A; Mps one binder kinase activator-like 1A; Protein Mob4A
Gene Symbols: MOB1B
Molecular weight: 25,091 Da
Basal Isoelectric point: 6.24  Predict pI for various phosphorylation states
CST Pathways:  Hippo Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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