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DUSP16 a non-receptor, dual-specificity phosphoprotein phosphatase (DUSP). Different members of the DUSP family show distinct substrate specificities for MAPKs, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. DUSP16 suppresses MAPK activation in the order of selectivity, JNK >> p38 > ERK, but interacts with ERK as well as JNK and p38. Overexpression of DUSP16 in BCR-ABL-transformed fibroblasts reduces their transforming capacity in vitro and in vivo via down regulation of BCR-ABL-induced JNK activation. DUSP16 might be haploinsufficient for tumor suppression. Contains 1 rhodanese domain. Note: This description may include information from UniProtKB.
Protein type: EC; EC; Protein phosphatase, dual-specificity
Chromosomal Location of Human Ortholog: 12p13.2
Cellular Component: cytoplasm; nucleoplasm; nucleus
Molecular Function: phosphoprotein phosphatase activity; phosphoric monoester hydrolase activity
Biological Process: dephosphorylation; inactivation of MAPK activity; MAPK export from nucleus; MAPK phosphatase export from nucleus, leptomycin B sensitive
Reference #:  Q9BY84 (UniProtKB)
Alt. Names/Synonyms: dual specificity phosphatase 16; Dual specificity protein phosphatase 16; DUS16; DUSP16; KIAA1700; MAP kinase phosphatase 7; MAPK phosphatase-7; MGC129701; MGC129702; Mitogen-activated protein kinase phosphatase 7; MKP-7; MKP7
Gene Symbols: DUSP16
Molecular weight: 73,102 Da
Basal Isoelectric point: 7.24  Predict pI for various phosphorylation states
CST Pathways:  SAPK/JNK Signaling Cascades
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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