a non-receptor, dual-specificity phosphoprotein phosphatase (DUSP). Different members of the DUSP family show distinct substrate specificities for MAPKs, different tissue distribution and subcellular localization, and different modes of induction by extracellular stimuli. Inactivates MAP kinases of the p38 and JNK subfamily, but not the ERK subfamily. Inhibits myogenesis and regeneration of skeletal muscle. It is evenly distributed in both the cytoplasm and the nucleus. Widely expressed in various tissues and organs, and its expression is elevated by stress stimuli. Inhibits intestinal epithelial cell growth. Mice deficient in expression of DUSP10 contained elevated levels of circulating IL-6 compared to wild type mice, apparently due to hyperphosphorylation of the DUSP10 substrate RAB3IL1. Elevated levels of expression in colorectal cancer patients were associated with improved survival probability. Two isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC 188.8.131.52; EC 184.108.40.206; Motility/polarity/chemotaxis; Protein phosphatase, dual-specificity
Biological Process: dephosphorylation; inactivation of MAPK activity; JNK cascade; negative regulation of JNK activity; positive regulation of regulatory T cell differentiation; protein amino acid dephosphorylation; response to stress