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AIM2 a tumor suppressor which may act by repressing NF-kappa-B transcriptional activity. Induced by interferon gamma. Defects in AIM2 may be a cause of microsatellite unstable colon cancers. AIM2 and various NOD-like receptors form multiprotein complexes called inflammasomes, which mediate caspase-1-dependent processing of pro-IL-1beta. Note: This description may include information from UniProtKB.
Protein type: Tumor suppressor
Chromosomal Location of Human Ortholog: 1q23.1-q23.2
Cellular Component: cytoplasm; cytosol; mitochondrion; nucleoplasm
Molecular Function: double-stranded DNA binding; identical protein binding; protein binding
Biological Process: activation of innate immune response; activation of NF-kappaB transcription factor; immune response; inhibition of NF-kappaB transcription factor; interleukin-1 beta secretion; positive regulation of defense response to virus by host; positive regulation of interleukin-1 beta production; positive regulation of interleukin-1 beta secretion; positive regulation of protein oligomerization; tumor necrosis factor-mediated signaling pathway
Reference #:  O14862 (UniProtKB)
Alt. Names/Synonyms: Absent in melanoma 2; AIM2; Interferon-inducible protein AIM2; PYHIN4
Gene Symbols: AIM2
Molecular weight: 38,954 Da
Basal Isoelectric point: 9.79  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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