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DUSP6 a non-receptor, dual-specificity phosphoprotein phosphatase. Different members of the DUSP family show distinct substrate specificities for MAPKs, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This protein inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: EC; EC; Motility/polarity/chemotaxis; Protein phosphatase, dual-specificity
Chromosomal Location of Human Ortholog: 12q21.33
Cellular Component: cytoplasm; cytosol; nucleoplasm
Molecular Function: MAP kinase tyrosine/serine/threonine phosphatase activity; protein tyrosine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity
Biological Process: activation of MAPK activity; dorsal/ventral pattern formation; inactivation of MAPK activity; MAPKKK cascade; positive regulation of apoptosis; regulation of endodermal cell fate specification; regulation of fibroblast growth factor receptor signaling pathway; response to nitrosative stress
Disease: Hypogonadotropic Hypogonadism 19 With Or Without Anosmia; Hypogonadotropic Hypogonadism 7 With Or Without Anosmia
Reference #:  Q16828 (UniProtKB)
Alt. Names/Synonyms: dual specificity phosphatase 6; Dual specificity protein phosphatase 6; Dual specificity protein phosphatase PYST1; DUS6; DUSP6; MAP kinase phosphatase 3; Mitogen-activated protein kinase phosphatase 3; MKP-3; MKP3; PYST1; serine/threonine specific protein phosphatase
Gene Symbols: DUSP6
Molecular weight: 42,320 Da
Basal Isoelectric point: 4.75  Predict pI for various phosphorylation states
CST Pathways:  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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