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PRC1 translocates to the plus ends of interdigitating spindle microtubules during the metaphase to anaphase transition, an essential step for the formation of an organized central spindle midzone and midbody and for successful cytokinesis. Acts as a microtubule-binding and bundling protein both in vivo and vitro. Interacts with the C-terminal Rho-GAP domain and the basic region of MgcRacGAP. The interaction with MgcRacGAP inhibits its GAP activity towards CDC42 in vitro, which may be required for maintaining normal spindle morphology. Interacts separately via its N-terminal region with the C-terminus of CENPE, KIF4A and KIF23 during late mitosis. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; Cytoskeletal; Microtubule-binding; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 15q26.1
Cellular Component: cytosol; microtubule cytoskeleton; midbody; nucleoplasm; nucleus; plasma membrane; spindle; spindle microtubule
Molecular Function: kinesin binding; protein binding; protein kinase binding
Biological Process: cytokinesis; mitotic spindle elongation; positive regulation of cell proliferation
Reference #:  O43663 (UniProtKB)
Alt. Names/Synonyms: anaphase spindle elongation 1 homolog; ASE1; MGC1671; MGC3669; PRC1; protein regulating cytokinesis 1; Protein regulator of cytokinesis 1
Gene Symbols: PRC1
Molecular weight: 71,607 Da
Basal Isoelectric point: 6.29  Predict pI for various phosphorylation states
CST Pathways:  Histone Methylation
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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