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SMAD6 Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit selectively BMP (bone morphogenetic proteins) signaling by competing with the co-SMAD SMAD4 for receptor-activated SMAD1. SMAD6 is an inhibitory SMAD (I-SMAD) or antagonistic SMAD. Binds to regulatory elements in target promoter regions. Interacts with NEDD4L. Interacts with WWP1. Interacts with RNF111 and AXIN1. Interacts with TGF-beta type I receptor superfamily members, SMAD1, HOXC8 and HOXC9. Interacts with STAMBP and PRKX. Ubiquitous in various organs, with higher levels in lung. Isoform B is up-regulated in diseased heart tissue. Belongs to the dwarfin/SMAD family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 15q22.31
Cellular Component: cytoplasm; cytosol; Golgi apparatus; nuclear body; nucleus; protein complex
Molecular Function: chromatin binding; identical protein binding; protein binding; transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity; ubiquitin protein ligase binding
Biological Process: BMP signaling pathway; cell-substrate adhesion; fat cell differentiation; immune response; negative regulation of apoptosis; negative regulation of BMP signaling pathway; negative regulation of cell proliferation; negative regulation of ossification; negative regulation of transforming growth factor beta receptor signaling pathway; zygotic determination of dorsal/ventral axis
Disease: Aortic Valve Disease 2; Craniosynostosis 7
Reference #:  O43541 (UniProtKB)
Alt. Names/Synonyms: hSMAD6; HsT17432; MAD homolog 6; MADH6; MADH7; Mothers against decapentaplegic homolog 6; Mothers against decapentaplegic, drosophila, homolog of, 6; Mothers against DPP homolog 6; SMAD 6; SMAD family member 6; SMAD, mothers against DPP homolog 6; SMAD6
Gene Symbols: SMAD6
Molecular weight: 53,497 Da
Basal Isoelectric point: 8.46  Predict pI for various phosphorylation states
CST Pathways:  TGF-ß Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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