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DUSP4 a non-receptor, dual-specificity phosphoprotein phosphatase (DUSP). Different members of the DUSP family show distinct substrate specificities for MAPKs, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. DUSP4 inactivates ERK1, ERK2 and JNK, is expressed in a variety of tissues, and is localized in the nucleus. Induced by hepatocyte growth factor (HGF) and vascular endothelial cell growth factor (VEGF) in human endothelial cells. Two alternatively spliced isoforms have been described. In addition, multiple polyadenylation sites have been reported. Contains 1 rhodanese domain. Note: This description may include information from UniProtKB.
Protein type: EC; EC; Protein phosphatase, dual-specificity
Chromosomal Location of Human Ortholog: 8p12
Cellular Component: nucleoplasm; nucleus
Molecular Function: phosphoric monoester hydrolase activity; protein tyrosine phosphatase activity; protein tyrosine/threonine phosphatase activity
Biological Process: dephosphorylation; endoderm formation; inactivation of MAPK activity
Reference #:  Q13115 (UniProtKB)
Alt. Names/Synonyms: dual specificity phosphatase 4; Dual specificity protein phosphatase 4; Dual specificity protein phosphatase hVH2; DUS4; DUSP4; HVH2; MAP kinase phosphatase 2; Mitogen-activated protein kinase phosphatase 2; MKP-2; MKP2; serine/threonine specific protein phosphatase; TYP; VH1 homologous phosphatase 2; VH2
Gene Symbols: DUSP4
Molecular weight: 42,953 Da
Basal Isoelectric point: 7.1  Predict pI for various phosphorylation states
CST Pathways:  Growth And Differentiation Control by MAPKs  |  SAPK/JNK Signaling Cascades
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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