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SARA Early endosomal protein that functions to recruit SMAD2/SMAD3 to intracellular membranes and to the TGF-beta receptor. Plays a significant role in TGF-mediated signaling by regulating the subcellular location of SMAD2 and SMAD3 and modulating the transcriptional activity of the SMAD3/SMAD4 complex. Possibly associated with TGF-beta receptor internalization. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 1p32.3
Cellular Component: cytosol; early endosome membrane; intracellular membrane-bound organelle; protein complex
Molecular Function: phosphatidylinositol binding; protein binding; protein domain specific binding
Biological Process: SMAD protein complex assembly; SMAD protein nuclear translocation; transforming growth factor beta receptor signaling pathway
Reference #:  O95405 (UniProtKB)
Alt. Names/Synonyms: hSARA; MAD homolog interacting protein; MAD, mothers against decapentaplegic homolog interacting protein, receptor activation anchor; Madh-interacting protein; MADHIP; mothers against decapentaplegic homolog interacting protein; Mothers against decapentaplegic homolog-interacting protein; Novel serine protease; NSP; Receptor activation anchor; SARA; Smad anchor for receptor activation; SMADIP; ZFYV9; ZFYVE9; Zinc finger FYVE domain-containing protein 9; zinc finger, FYVE domain containing 9
Gene Symbols: ZFYVE9
Molecular weight: 156,403 Da
Basal Isoelectric point: 4.89  Predict pI for various phosphorylation states
CST Pathways:  ESC Pluripotency and Differentiation  |  TGF-ß Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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