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ERK1 a serine/threonine kinase of the GMGC group that plays a critical role in the regulation of cell growth and differentiation. ERK1 (MAPK3) and ERK2 (MAPK1) play central roles in MAPK cascades and are activated by a wide variety of extracellular signals including growth and neurotrophic factors, cytokines, hormones and neurotransmitters. Depending on the cellular context, MAPK cascades mediate diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. MAPK cascades also plays a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. Activation of MAP kinases occurs through phosphorylation of threonine and tyrosine residues at the sequence T*EY* by upstream MAP kinase kinases, MEK1 and -2. Phosphorylation of both the threonine and tyrosine are required for activity. This phosphorylation causes dramatic conformational changes, which enable full activation and interaction of MAPK1/ERK2 with its substrates. Note: This description may include information from UniProtKB.
Protein type: CMGC group; EC; ERK subfamily; Kinase, protein; MAPK family; MAPK/ERK subfamily; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 7 F3|7 69.25 cM
Cellular Component: caveola; cytoplasm; cytoskeleton; cytosol; early endosome; focal adhesion; Golgi apparatus; late endosome; mitochondrion; nuclear envelope; nucleoplasm; nucleus; protein complex; pseudopodium
Molecular Function: ATP binding; MAP kinase activity; MAP kinase kinase activity; phosphatase binding; phosphotyrosine binding; protein binding; protein kinase activity
Biological Process: Bergmann glial cell differentiation; BMP signaling pathway; cartilage development; cellular response to amino acid starvation; DNA damage induced protein phosphorylation; lipopolysaccharide-mediated signaling pathway; MAPKKK cascade; neural crest cell development; nuclear translocation of MAPK; organ morphogenesis; outer ear morphogenesis; peptidyl-serine phosphorylation; phosphorylation; positive regulation of cyclase activity; positive regulation of cytokine secretion during immune response; positive regulation of histone acetylation; positive regulation of histone phosphorylation; positive regulation of protein amino acid phosphorylation; positive regulation of telomerase activity; positive regulation of telomere maintenance via telomerase; positive regulation of transcription from RNA polymerase II promoter; positive regulation of translation; protein amino acid phosphorylation; protein complex assembly; regulation of cellular pH; regulation of cytoskeleton organization and biogenesis; regulation of ossification; regulation of stress-activated MAPK cascade; regulation of transcription factor activity; response to DNA damage stimulus; response to exogenous dsRNA; response to lipopolysaccharide; response to toxin; sensory perception of pain; signal transduction; stress-activated MAPK cascade; thymus development; thyroid gland development; transcription, DNA-dependent
Reference #:  Q63844 (UniProtKB)
Alt. Names/Synonyms: ERK; ERK-1; Erk1; ERT2; Esrk1; Extracellular signal-regulated kinase 1; Insulin-stimulated MAP2 kinase; MAP kinase 1; MAP kinase 3; MAP kinase isoform p44; MAPK 1; MAPK 3; Mapk3; Microtubule-associated protein 2 kinase; mitogen activated protein kinase 3; Mitogen-activated protein kinase 1; Mitogen-activated protein kinase 3; MK03; MNK1; Mtap2k; OTTMUSP00000017735; p44; p44 MAP kinase; p44-ERK1; p44-MAPK; p44erk1; p44mapk; pp42/MAP kinase; Prkm3; protein kinase, mitogen activated kinase 3
Gene Symbols: Mapk3
Molecular weight: 43,066 Da
Basal Isoelectric point: 6.15  Predict pI for various phosphorylation states
CST Pathways:  Angiogenesis  |  Apoptosis Regulation  |  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  ESC Pluripotency and Differentiation  |  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs  |  IL6 Signaling  |  Inhibition of Apoptosis  |  Insulin Receptor Signaling  |  Microtubule Dynamics  |  Mitochondrial Control of Apoptosis  |  mTOR Signaling  |  T Cell Receptor Signaling  |  TGF-ß Signaling  |  Translation: eIF4E and p70S6K  |  Warburg Effect
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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