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PIP4K2B Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. Homodimer. Binds TNFRSF1A. Interacts with PIP4K2A. Interaction with PIP4K2A suppresses ubiquitination by the SPOP/ CUL3 complex. Highly expressed in brain, heart, pancreas, skeletal muscle and kidney. Detected at lower levels in placenta, lung and liver. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - inositol phosphate; EC; Kinase, lipid; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 17q12
Cellular Component: autophagic vacuole; cytosol; nucleoplasm
Molecular Function: 1-phosphatidylinositol-4-phosphate 5-kinase activity; 1-phosphatidylinositol-5-phosphate 4-kinase activity; protein binding; protein homodimerization activity; receptor signaling protein activity
Biological Process: cell surface receptor linked signal transduction; phosphatidylinositol biosynthetic process; phospholipid metabolic process; regulation of autophagy; regulation of phosphoinositide 3-kinase cascade
Reference #:  P78356 (UniProtKB)
Alt. Names/Synonyms: 1-phosphatidylinositol-4-phosphate kinase; 1-phosphatidylinositol-5-phosphate 4-kinase 2-beta; Diphosphoinositide kinase 2-beta; phosphatidylinositol-4-phosphate 5-kinase, type II, beta; Phosphatidylinositol-5-phosphate 4-kinase type II beta; Phosphatidylinositol-5-phosphate 4-kinase type-2 beta; phosphatidylinositol-5-phosphate 4-kinase, type II, beta; PI(5)P 4-kinase type II beta; PI42B; PI5P4KB; PIP4K2B; PIP4KII-beta; PIP5K2B; PIP5KIIB; PIP5KIIbeta; PTDINS(4)P-5-kinase; PtdIns(5)P-4-kinase isoform 2-beta
Gene Symbols: PIP4K2B
Molecular weight: 47,378 Da
Basal Isoelectric point: 6.9  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  PI3K/Akt Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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