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Protein Page:
CD68

Overview
CD68 Could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. Binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells. Belongs to the LAMP family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cell surface; Membrane protein, integral
Chromosomal Location of Human Ortholog: 17p13.1
Cellular Component: endosome membrane; integral component of membrane; membrane; plasma membrane
Biological Process: neutrophil degranulation
Reference #:  P34810 (UniProtKB)
Alt. Names/Synonyms: CD68; CD68 antigen; CD68 molecule; DKFZp686M18236; Gp110; macrophage antigen CD68; Macrosialin; SCARD1; scavenger receptor class D, member 1
Gene Symbols: CD68
Molecular weight: 37,408 Da
Basal Isoelectric point: 9.1  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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CD68

Protein Structure Not Found.

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