Binding of FREAC-3 and FREAC-4 to their cognate sites results in bending of the DNA at an angle of 80-90 degrees. Monomer. Expressed in all tissues and cell lines examined. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; Cell development/differentiation; DNA-binding; Transcription factor
Molecular Function: DNA bending activity; DNA binding; protein binding; sequence-specific DNA binding; transcription coactivator activity; transcription factor activity; transcription factor binding
Biological Process: cell migration; cell proliferation; cerebellum development; endochondral ossification; eye development; heart development; kidney development; mesenchymal cell development; negative regulation of angiogenesis; negative regulation of mitotic cell cycle; negative regulation of transcription from RNA polymerase II promoter; odontogenesis of dentine-containing teeth; positive regulation of DNA binding; positive regulation of keratinocyte differentiation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of transcription, DNA-dependent; ureteric bud development