an AGC kinase of the PKC family. A classical PKC downstream of many mitogenic receptors. Activates the NF-kappaB signaling pathway in B cells after antigen-receptor signaling. Two splice-variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: AGC group; Alpha subfamily; EC 18.104.22.168; Kinase, protein; Motility/polarity/chemotaxis; PKC family; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)
Molecular Function: androgen receptor binding; ATP binding; calcium channel regulator activity; calcium-dependent protein kinase C activity; chromatin binding; histone binding; ligand-dependent nuclear receptor transcription coactivator activity; protein binding; protein kinase C activity; protein kinase C binding; protein serine/threonine kinase activity; zinc ion binding
Biological Process: adaptive immune response; apoptosis; B cell activation; B cell receptor signaling pathway; calcium ion transport; cellular calcium ion homeostasis; cellular response to carbohydrate stimulus; lipoprotein transport; mitotic nuclear envelope disassembly; negative regulation of glucose transport; negative regulation of insulin receptor signaling pathway; peptidyl-serine phosphorylation; platelet activation; positive regulation of angiogenesis; positive regulation of B cell receptor signaling pathway; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of NF-kappaB transcription factor activity; positive regulation of vascular endothelial growth factor receptor signaling pathway; protein amino acid phosphorylation; regulation of myeloid cell differentiation; regulation of transcription from RNA polymerase II promoter; response to hypoxia; signal transduction; transcription, DNA-dependent