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PRIM1 DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication. Heterodimer of a small subunit and a large subunit. Belongs to the eukaryotic-type primase small subunit family. Note: This description may include information from UniProtKB.
Protein type: DNA replication; EC 2.7.7.-; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine; Transferase
Chromosomal Location of Human Ortholog: 12q13.3
Cellular Component: alpha DNA polymerase:primase complex; membrane; nucleoplasm
Molecular Function: DNA primase activity; single-stranded DNA binding
Biological Process: DNA replication initiation; DNA replication, synthesis of RNA primer; G1/S transition of mitotic cell cycle; telomere maintenance via recombination
Reference #:  P49642 (UniProtKB)
Alt. Names/Synonyms: DNA primase 1; DNA primase 49 kDa subunit; DNA primase polypeptide 1; DNA primase small subunit; DNA primase subunit 48; MGC12308; p49; PRI1; PRIM1; primase p49 subunit; primase polypeptide 1, 49kDa; primase, DNA, polypeptide 1 (49kDa)
Gene Symbols: PRIM1
Molecular weight: 49,902 Da
Basal Isoelectric point: 8.39  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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