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DR1 The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. Heterodimer with DRAP1. DR1 exists in solution as a homotetramer that dissociates during interaction with TBP and then, after complexing with TBP, reassociates at a slow rate, to reconstitute the tetramer. Interacts with NFIL3. Component of the ADA2A-containing complex (ATAC), composed of CSRP2BP, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5, YEATS2, CCDC101 and DR1. Belongs to the NC2 beta/DR1 family. Note: This description may include information from UniProtKB.
Protein type: Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 1p22.1
Cellular Component: nucleus
Molecular Function: protein binding; TATA-binding protein binding; transcription corepressor activity; transcription factor binding
Biological Process: negative regulation of transcription from RNA polymerase II promoter
Reference #:  Q01658 (UniProtKB)
Alt. Names/Synonyms: Down-regulator of transcription 1; down-regulator of transcription 1, TBP-binding (negative cofactor 2); DR1; NC2; NC2-beta; NC2B; Negative cofactor 2-beta; Protein Dr1; TATA-binding protein-associated phosphoprotein
Gene Symbols: DR1
Molecular weight: 19,444 Da
Basal Isoelectric point: 4.69  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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