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MCM7 Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for S-phase checkpoint activation upon UV-induced damage. Component of the MCM2-7 complex. The complex forms a toroidal hexameric ring with the proposed subunit order MCM2-MCM6- MCM4-MCM7-MCM3-MCM5 (By simililarity). Interacts with the ATR- ATRIP complex and with RAD17. Interacts with TIPIN. Interacts with MCMBP. Belongs to the MCM family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: DNA replication; EC; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 7q22.1
Cellular Component: chromatin; cytosol; MCM complex; membrane; nuclear chromosome, telomeric region; nucleolus; nucleoplasm; nucleus
Molecular Function: ATP-dependent DNA helicase activity; DNA binding; protein binding
Biological Process: DNA replication; G1/S transition of mitotic cell cycle; regulation of phosphorylation; response to DNA damage stimulus
Reference #:  P33993 (UniProtKB)
Alt. Names/Synonyms: CDC47; CDC47 homolog; DNA replication licensing factor MCM7; homolog of S. cerevisiae Cdc47; MCM2; MCM7; minichromosome maintenance complex component 7; minichromosome maintenance deficient 7; P1.1-MCM3; P1CDC47; P85MCM; PNAS146
Gene Symbols: MCM7
Molecular weight: 81,308 Da
Basal Isoelectric point: 6.08  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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