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SP1 a transcription factor of the Sp1 C2H2-type zinc-finger protein family. Phosphorylated and activated by MAPK. Dephosphorylation by PTEN inhibits DNA binding. Binds to p38 in the nucleus. Interacts with Huntingtin and TAFII130. Transcriptional activity of SP1 and TAFII130 disrupted in early Huntingtin's Disease. Note: This description may include information from UniProtKB.
Protein type: C2H2-type zinc finger protein; DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 12q13.13
Cellular Component: nuclear chromatin; nucleoplasm; nucleus; transcriptional repressor complex
Molecular Function: bHLH transcription factor binding; DNA binding; double-stranded DNA binding; histone deacetylase binding; protein binding; protein C-terminus binding; protein homodimerization activity; sequence-specific DNA binding; transcription factor activity; transcription factor binding
Biological Process: positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of cholesterol biosynthetic process; regulation of transcription, DNA-dependent; snRNA transcription from RNA polymerase II promoter
Reference #:  P08047 (UniProtKB)
Alt. Names/Synonyms: SP1; Sp1 transcription factor; specificity protein 1; Transcription factor Sp1; TSFP1
Gene Symbols: SP1
Molecular weight: 80,693 Da
Basal Isoelectric point: 6.94  Predict pI for various phosphorylation states
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