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PTPRA a receptor protein tyrosine phosphatase (PTP). Contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains. Dephosphorylates and activates Src family tyrosine kinases, and is implicated in the regulation of integrin signaling, cell adhesion and proliferation. Four alternatively spliced isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor protein phosphatase, tyrosine
Chromosomal Location of Human Ortholog: 20p13
Cellular Component: extracellular exosome; integral component of plasma membrane; intracellular; plasma membrane; receptor complex
Molecular Function: protein binding; protein tyrosine phosphatase activity; Ras guanyl-nucleotide exchange factor activity; transmembrane receptor protein tyrosine phosphatase activity
Biological Process: axon guidance; insulin receptor signaling pathway; MAPK cascade; regulation of molecular function
Reference #:  P18433 (UniProtKB)
Alt. Names/Synonyms: HEPTP; HLPR; HPTPA; HPTPalpha; Leukocyte common antigen-related peptide (protein tyrosine phosphate); LRP; protein tyrosine phosphatase, receptor type, A; protein tyrosine phosphatase, receptor type, alpha polypeptide; Protein-tyrosine phosphatase alpha; PTPase-alpha; PTPLCA-related phosphatase; PTPRL2; R-PTP-alpha; Receptor-type tyrosine-protein phosphatase alpha; RPTPA; tyrosine phosphatase alpha
Gene Symbols: PTPRA
Molecular weight: 90,600 Da
Basal Isoelectric point: 6.26  Predict pI for various phosphorylation states
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Protein Structure Not Found.
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