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Protein Page:

EIF4A2 ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon. Belongs to the DEAD box helicase family. eIF4A subfamily. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC; Helicase; RNA-binding; Translation; Translation initiation
Chromosomal Location of Human Ortholog: 3q27.3
Cellular Component: cytosol; eukaryotic translation initiation factor 4F complex; nucleolus; perinuclear region of cytoplasm
Molecular Function: ATP-dependent RNA helicase activity; ATPase activity; helicase activity; protein binding; RNA binding
Biological Process: poly(A) tail shortening; regulation of translational initiation; RNA secondary structure unwinding; translational initiation
Reference #:  Q14240 (UniProtKB)
Alt. Names/Synonyms: ATP-dependent RNA helicase eIF4A-2; BM-010; DDX2B; eIF-4A-II; EIF4A; eIF4A-II; EIF4A2; EIF4F; Eukaryotic initiation factor 4A-II; eukaryotic translation initiation factor 4A, isoform 2; eukaryotic translation initiation factor 4A2; IF4A2
Gene Symbols: EIF4A2
Molecular weight: 46,402 Da
Basal Isoelectric point: 5.33  Predict pI for various phosphorylation states
CST Pathways:  Translation: eIF4E and p70S6K  |  Translational Control
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Protein Structure Not Found.
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