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Pumilio-1 Sequence-specific RNA-binding protein that regulates translation and mRNA stability by binding the 3'-UTR of mRNA targets. May be required to support proliferation and self-renewal of stem cells. Strongly down-regulated in keratinocytes upon ultraviolet B radiation. Binds in a sequence-specific manner to the 3'-UTR of some mRNAs. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: RNA-binding; Translation
Chromosomal Location of Human Ortholog: 1p35.2
Cellular Component: cytosol; nuclear speck; nucleoplasm; nucleus; stress granule
Molecular Function: mRNA 3'-UTR binding; protein binding; RNA binding
Biological Process: adult locomotory behavior; posttranscriptional gene silencing; regulation of cell cycle; regulation of chromosome segregation; regulation of mRNA stability; spermatogenesis; stem cell differentiation
Reference #:  Q14671 (UniProtKB)
Alt. Names/Synonyms: HsPUM; KIAA0099; PUM1; PUMH; PUMH1; Pumilio homolog 1; pumilio homolog 1 (Drosophila); Pumilio-1; PUML1
Gene Symbols: PUM1
Molecular weight: 126,473 Da
Basal Isoelectric point: 6.35  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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