Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
Home | Login
About PhosphoSiteUsing PhosphoSiteprivacy & cookiesCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Search / Browse Functions
Protein Page:

PD-1 a single-pass type I membrane protein. A negative regulator of activated T cells, is upregulated in human and mouse 'exhausted' T cells during persistent viral infection. A marker of angioimmunoblastic T-cell lymphoma and germinal center associated T cells. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; Membrane protein, integral
Chromosomal Location of Human Ortholog: 2q37.3
Cellular Component: external side of plasma membrane; integral component of membrane; plasma membrane
Molecular Function: protein binding; signal transducer activity
Biological Process: apoptosis; humoral immune response; multicellular organism development; negative regulation of apoptosis; negative regulation of tolerance induction; signal transduction; T cell costimulation
Disease: Systemic Lupus Erythematosus
Reference #:  Q15116 (UniProtKB)
Alt. Names/Synonyms: CD279; hPD-1; hPD-l; PD1; PDCD1; programmed cell death 1; Programmed cell death protein 1; Protein PD-1; SLEB2
Gene Symbols: PDCD1
Molecular weight: 31,647 Da
Basal Isoelectric point: 8.25  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script

STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein