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CDC45L Required for initiation of chromosomal DNA replication. Associated with ORC2. Widely expressed, highest levels are found in adult testis and thymus and in fetal liver. Belongs to the CDC45 family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation
Chromosomal Location of Human Ortholog: 22q11.21
Cellular Component: centrosome; nucleoplasm; nucleus
Molecular Function: 3'-5' DNA helicase activity; chromatin binding; DNA replication origin binding; protein binding; single-stranded DNA binding
Biological Process: DNA replication; DNA replication checkpoint; DNA replication initiation; double-strand break repair via break-induced replication; G1/S transition of mitotic cell cycle; G1/S-specific transcription in mitotic cell cycle; pre-replicative complex assembly; regulation of chromatin silencing at telomere
Disease: Meier-gorlin Syndrome 7
Reference #:  O75419 (UniProtKB)
Alt. Names/Synonyms: CC45L; Cdc45; CDC45 (cell division cycle 45, S.cerevisiae, homolog)-like; CDC45 cell division cycle 45 homolog (S. cerevisiae); CDC45 cell division cycle 45-like; CDC45-related protein; CDC45L; CDC45L2; cell division cycle 45-like 2; human CDC45; PORC-PI-1
Gene Symbols: CDC45
Molecular weight: 65,569 Da
Basal Isoelectric point: 5.31  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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