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ECGF1 May have a role in maintaining the integrity of the blood vessels. Has growth promoting activity on endothelial cells, angiogenic activity in vivo and chemotactic activity on endothelial cells in vitro. Homodimer. Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Note: This description may include information from UniProtKB.
Protein type: Cytokine; DNA replication; EC; Motility/polarity/chemotaxis; Nucleotide Metabolism - pyrimidine; Phosphorylase; Transferase; Xenobiotic Metabolism - drug metabolism - other enzymes
Chromosomal Location of Human Ortholog: 22q13.33
Cellular Component: cytosol
Molecular Function: phosphorylase activity; protein homodimerization activity; thymidine phosphorylase activity; transferase activity, transferring pentosyl groups
Biological Process: mitochondrial genome maintenance; pyrimidine nucleoside catabolic process; pyrimidine nucleoside metabolic process; pyrimidine nucleoside salvage; regulation of myelination; regulation of transmission of nerve impulse
Disease: Mitochondrial Dna Depletion Syndrome 1 (mngie Type)
Reference #:  P19971 (UniProtKB)
Alt. Names/Synonyms: ECGF1; endothelial cell growth factor 1 (platelet-derived); Gliostatin; hPD-ECGF; MNGIE; PD-ECGF; PDECGF; Platelet-derived endothelial cell growth factor; TdRPase; Thymidine phosphorylase; TP; TYMP; TYPH
Gene Symbols: TYMP
Molecular weight: 49,955 Da
Basal Isoelectric point: 5.36  Predict pI for various phosphorylation states
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