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BCAT1 Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - valine, leucine and isoleucine biosynthesis; Amino Acid Metabolism - valine, leucine and isoleucine degradation; Cofactor and Vitamin Metabolism - pantothenate and CoA biosynthesis; EC; Transferase
Chromosomal Location of Human Ortholog: 12p12.1
Cellular Component: cytosol; mitochondrion
Molecular Function: branched-chain-amino-acid transaminase activity
Biological Process: branched chain family amino acid biosynthetic process; branched chain family amino acid catabolic process; cell proliferation; G1/S transition of mitotic cell cycle; leucine biosynthetic process; valine biosynthetic process
Reference #:  P54687 (UniProtKB)
Alt. Names/Synonyms: BCAT(c); BCAT1; BCT1; branched chain aminotransferase 1, cytosolic; Branched-chain-amino-acid aminotransferase, cytosolic; DKFZp686E12175; ECA39; MECA39; placental protein 18; PNAS-121; PP18; Protein ECA39
Gene Symbols: BCAT1
Molecular weight: 42,966 Da
Basal Isoelectric point: 5.17  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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