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CTSD Acid protease active in intracellular protein breakdown. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease. Consists of a light chain and a heavy chain. Belongs to the peptidase A1 family. Note: This description may include information from UniProtKB.
Protein type: Autophagy; EC; Motility/polarity/chemotaxis; Protease
Chromosomal Location of Human Ortholog: 11p15.5
Cellular Component: extracellular matrix; extracellular region; extracellular space; lipid raft; lysosomal lumen; lysosome
Molecular Function: aspartic-type endopeptidase activity; cysteine-type endopeptidase activity; protein binding; serine-type endopeptidase activity
Biological Process: antigen processing and presentation of exogenous peptide antigen via MHC class II; autophagy; collagen catabolic process; neutrophil degranulation; protein catabolic process; proteolysis
Disease: Ceroid Lipofuscinosis, Neuronal, 10
Reference #:  P07339 (UniProtKB)
Alt. Names/Synonyms: CATD; Cathepsin D; Cathepsin D heavy chain; Cathepsin D light chain; ceroid-lipofuscinosis, neuronal 10; CLN10; CPSD; CTSD; lysosomal aspartyl peptidase; lysosomal aspartyl protease; MGC2311
Gene Symbols: CTSD
Molecular weight: 44,552 Da
Basal Isoelectric point: 6.1  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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