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SYP Possibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane. Involved in the regulation of short-term and long-term synaptic plasticity. Homohexamer or homotetramer. Interacts with SRCIN1. Characteristic of a type of small (30-80 nm) neurosecretory vesicles, including presynaptic vesicles, but also vesicles of various neuroendocrine cells of both neuronal and epithelial phenotype. Belongs to the synaptophysin/synaptobrevin family. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Vesicle
Chromosomal Location of Human Ortholog: Xp11.23
Cellular Component: integral to synaptic vesicle membrane; neuron projection; synaptic vesicle
Molecular Function: cholesterol binding; protein self-association
Biological Process: endocytosis; regulation of long-term neuronal synaptic plasticity; regulation of neuronal synaptic plasticity; regulation of short-term neuronal synaptic plasticity
Disease: Mental Retardation, X-linked 96
Reference #:  P08247 (UniProtKB)
Alt. Names/Synonyms: Major synaptic vesicle protein p38; MRXSYP; Synaptophysin; SYP; SYPH
Gene Symbols: SYP
Molecular weight: 33,845 Da
Basal Isoelectric point: 4.66  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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