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Protein Page:
Ig-beta

Overview
Ig-beta Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation. Defects in CD79B are the cause of agammaglobulinemia type 6 (AGM6). It is a primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B-cells due to an early block of B-cell development. Affected individuals develop severe infections in the first years of life. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Receptor, misc.
Chromosomal Location of Human Ortholog: 17q23.3
Cellular Component: B cell receptor complex; cytoplasm; cytosol; external side of plasma membrane; Golgi apparatus; integral component of plasma membrane; nucleoplasm; plasma membrane
Molecular Function: protein binding; protein homodimerization activity; transmembrane receptor activity
Biological Process: adaptive immune response; B cell differentiation; B cell receptor signaling pathway; immune response; protein homooligomerization; signal transduction
Disease: Agammaglobulinemia 6, Autosomal Recessive
Reference #:  P40259 (UniProtKB)
Alt. Names/Synonyms: B-cell antigen receptor complex-associated protein beta chain; B-cell-specific glycoprotein B29; B29; CD79B; CD79B antigen; CD79b antigen (immunoglobulin-associated beta); CD79b molecule, immunoglobulin-associated beta; Ig-beta; IGB; Immunoglobulin-associated B29 protein
Gene Symbols: CD79B
Molecular weight: 26,048 Da
Basal Isoelectric point: 5.67  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Ig-beta

Protein Structure Not Found.
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