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CD151 Essential for the proper assembly of the glomerular and tubular basement membranes in kidney. Defects in CD151 are the cause of nephropathy with pretibial epidermolysis bullosa and deafness (NPEBD). NPEBD is characterized by the association of hereditary nephritis, epidermolysis bullosa, deafness, and beta-thalassemia minor. Belongs to the tetraspanin (TM4SF) family. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 11p15.5
Cellular Component: basement membrane; cytosol; focal adhesion; integral component of plasma membrane; membrane; plasma membrane
Molecular Function: integrin binding; protein binding
Biological Process: cell adhesion; cell migration; cell surface receptor signaling pathway; hemidesmosome assembly; T cell proliferation
Disease: Nephropathy With Pretibial Epidermolysis Bullosa And Deafness; Raph Blood Group System
Reference #:  P48509 (UniProtKB)
Alt. Names/Synonyms: CD151; CD151 antigen; CD151 antigen (Raph blood group); CD151 molecule (Raph blood group); GP27; hemidesmosomal tetraspanin CD151; Membrane glycoprotein SFA-1; MER2; PETA-3; platelet surface glycoprotein gp27; platelet-endothelial cell tetraspan antigen 3; Platelet-endothelial tetraspan antigen 3; RAPH; SFA1; Tetraspanin-24; Tspan-24; TSPAN24
Gene Symbols: CD151
Molecular weight: 28,295 Da
Basal Isoelectric point: 7.45  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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