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LIMS1 Effector of integrin and growth factor signaling, coupling surface receptors to downstream signaling molecules involved in the regulation of cell survival, cell proliferation and cell differentiation. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. 5 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 2q12.3
Cellular Component: cytosol; focal adhesion; intercellular junction; perinuclear region of cytoplasm
Molecular Function: protein binding; protein kinase binding; zinc ion binding
Biological Process: cell aging; epithelial to mesenchymal transition; establishment of protein localization; negative regulation of transcription, DNA-dependent; positive regulation of focal adhesion formation; positive regulation of GTPase activity; regulation of epithelial cell proliferation; tumor necrosis factor-mediated signaling pathway
Reference #:  P48059 (UniProtKB)
Alt. Names/Synonyms: LIM and senescent cell antigen-like domains 1; LIM and senescent cell antigen-like-containing domain protein 1; LIMS1; Particularly interesting new Cys-His protein 1; PINCH; PINCH-1; PINCH1; Renal carcinoma antigen NY-REN-48
Gene Symbols: LIMS1
Molecular weight: 37,251 Da
Basal Isoelectric point: 8.43  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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